Interaction #1 NFATC1 - GSK3B
(1) MOD_GSK3_1 motif (287PHGSPRVS294) in Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1)
(2) Protein kinase domain (56-340) in Glycogen synthase kinase-3 beta (GSK3B)
PTM-dependent Induction (Phosphorylation of S294 on Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1)) of the Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1) MOD_GSK3_1 motif - Glycogen synthase kinase-3 beta (GSK3B) Protein kinase domain interaction
Regulatory Enzymes for switch
Modifying enzymes for residue: S294: cAMP subfamily
Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: S294 : PKA_group, cAMP-dependent protein kinase catalytic subunit alpha (PRKACA).
ELM curated: cytosol, nucleus
(1) Protein kinase A negatively modulates the nuclear accumulation of NF-ATc1 by priming for subsequent phosphorylation by glycogen synthase kinase-3.
Other switches involving participants