Switches.ELM

Switch #:

SWTI000010

Switch type:
Binary

Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y530 in the SH2-binding motif of Proto-oncogene tyrosine-protein kinase Src (SRC) induces an intramolecular interaction with the SH2 domain of Proto-oncogene tyrosine-protein kinase Src (SRC) resulting in inhibition of its activity and preventing intermolecular interactions of its SH2 domain.

Participants:
(1) Proto-oncogene tyrosine-protein kinase Src (SRC)

Interactions

Interaction #1 SRC - SRC(intramolecular)
intramolecular
Interfaces
(1) LIG_SH2_SRC motif (₅₃₀YQPG₅₃₃) in Proto-oncogene tyrosine-protein kinase Src (SRC)
(2) SH2 domain_(151-233) in Proto-oncogene tyrosine-protein kinase Src (SRC)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y₅₃₀ on Proto-oncogene tyrosine-protein kinase Src (SRC)) of the Proto-oncogene tyrosine-protein kinase Src (SRC) LIG_SH2_SRC motif - Proto-oncogene tyrosine-protein kinase Src (SRC) SH2 domain interaction

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: Y₅₃₀ : Proto-oncogene tyrosine-protein kinase Src (SRC), Proto-oncogene tyrosine-protein kinase Src (Src), Tyrosine-protein kinase CSK (CSK).

Additional Information
Structural information: 2SRC

Context

Switch localisation
ELM curated: cytosol

References

(1) Kinome signaling through regulated protein-protein interactions in normal and cancer cells.
Pawson et al. Curr. Opin. Cell Biol. (2009)