Motif | Protein | Start | End | Switch Type | Switch Subtype | Switch description | Information | Evidence |
PKC subfamily | ||||||||
DOC_CYCLIN_1 | AKA12_MOUSE | 501 | 504 | Binary | Physicochemical compatibility | Phosphorylation of S507 adjacent to the cyclin-binding motif of A-kinase anchor protein 12 (Akap12) by PKC subfamily blocks binding to the G1/S-specific cyclin-D1 (Ccnd1). As a result, the function of A-kinase anchor protein 12 (Akap12) as a scaffold is inhibited and G1/S-specific cyclin-D1 (Ccnd1) is translocated to the nucleus where it regulates progression of the cell cycle from G1 to S phase. | Curated |