Serine/threonine-protein kinase CBK1 (Saccharomyces) | Serine/threonine-protein kinase PLK1 | Serine/threonine-protein kinase PLK3 |
Motif | Protein | Start | End | Switch Type | Switch Subtype | Switch description | Information | Evidence |
Serine/threonine-protein kinase CBK1 - CBK1 -  Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | ||||||||
TRG_NES | ACE2_YEAST | 122 | 150 | Binary | Physicochemical compatibility | Phosphorylation of S137 in the NES of Metallothionein expression activator (ACE2) inhibits binding to Exportin-1 (CRM1). Phosphorylation of S137, and to a lesser extent S122, by Cbk1 directly antagonizes the interaction of Ace2 with nuclear export machinery. | Curated | |
TRG_NES | ACE2_YEAST | 122 | 150 | Binary | Physicochemical compatibility | Phosphorylation of S122 in the NES of Metallothionein expression activator (ACE2) inhibits binding to Exportin-1 (CRM1). Phosphorylation of S137, and to a lesser extent S122, by Cbk1 directly antagonizes the interaction of Ace2 with nuclear export machinery. | Curated | |
Serine/threonine-protein kinase PLK1 - PLK1 -  Homo sapiens | ||||||||
TRG_NES_CRM1_1 | MPIP3_HUMAN | 189 | 203 | Binary | Physicochemical compatibility | Phosphorylation of S198 in the NES of M-phase inducer phosphatase 3 (CDC25C) by Serine/threonine-protein kinase PLK1 (PLK1) inhibits binding to Exportin-1 (XPO1), thus promoting nuclear localization of M-phase inducer phosphatase 3 (CDC25C). | Curated | |
Serine/threonine-protein kinase PLK3 - PLK3 -  Homo sapiens | ||||||||
TRG_NES_CRM1_1 | MPIP3_HUMAN | 189 | 203 | Binary | Physicochemical compatibility | Phosphorylation of S198 in the NES of M-phase inducer phosphatase 3 (CDC25C) by Serine/threonine-protein kinase PLK1 (PLK1) inhibits binding to Exportin-1 (XPO1), thus promoting nuclear localization of M-phase inducer phosphatase 3 (CDC25C). | Inferred | |
TRG_NES_CRM1_1 | MPIP3_HUMAN | 189 | 203 | Binary | Physicochemical compatibility | Phosphorylation of S198 in the NES of M-phase inducer phosphatase 3 (CDC25C) by Serine/threonine-protein kinase PLK1 (PLK1) inhibits binding to Exportin-1 (XPO1), thus promoting nuclear localization of M-phase inducer phosphatase 3 (CDC25C). | Inferred |