switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Hide inferred Group Index Colouring Info Filtered: UNIPROT:O14745 (3 hits) x

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Curated inferred

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Beta-adrenergic receptor kinase 1

Beta-adrenergic receptor kinase 1 (Bos)

G protein-coupled receptor kinase 5

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Protein

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Evidence

Beta-adrenergic receptor kinase 1 - ADRBK1 - Bos taurus
LIG_PDZ_Class_1	PGFRB_HUMAN	1101	1106	Binary	Physicochemical compatibility	Phosphorylation of S1104 in the PDZ-binding motif of Platelet-derived growth factor receptor beta (PDGFRB) by Beta-adrenergic receptor kinase 1 (ADRBK1) inhibits binding to Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (SLC9A3R1). Binding of Platelet-derived growth factor receptor beta (PDGFRB) to Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (SLC9A3R1) potentiates dimerisation and signalling of the receptor, while phosphorylation at S1104 desensitises the receptor.	details	Inferred
Beta-adrenergic receptor kinase 1 - ADRBK1 - Homo sapiens
LIG_PDZ_Class_1	PGFRB_HUMAN	1101	1106	Binary	Physicochemical compatibility	Phosphorylation of S1104 in the PDZ-binding motif of Platelet-derived growth factor receptor beta (PDGFRB) by Beta-adrenergic receptor kinase 1 (ADRBK1) inhibits binding to Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (SLC9A3R1). Binding of Platelet-derived growth factor receptor beta (PDGFRB) to Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (SLC9A3R1) potentiates dimerisation and signalling of the receptor, while phosphorylation at S1104 desensitises the receptor.	details	Curated
G protein-coupled receptor kinase 5 - GRK5 - Homo sapiens
LIG_PDZ_Class_1	ADRB2_HUMAN	408	413	Binary	Physicochemical compatibility	Phosphorylation of S411 in the PDZ-binding motif of Beta-2 adrenergic receptor (ADRB2) by inhibits its interaction with the Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (SLC9A3R1) protein.	details	Curated