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Switch #:
SWTI000208
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of S411 in the PDZ-binding motif of Beta-2 adrenergic receptor (ADRB2) by inhibits its interaction with the Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (SLC9A3R1) protein.

Participants:
(1) Beta-2 adrenergic receptor (ADRB2)
(2) Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (SLC9A3R1)

Interactions
Interaction #1 ADRB2 - SLC9A3R1

Interfaces
(1) LIG_PDZ_Class_1 motif (408TNDSLL413) in Beta-2 adrenergic receptor (ADRB2)
(2) PDZ domain (Also known as DHR or GLGF) (16-91) in Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (SLC9A3R1)

Interaction Regulation
PTM-dependent Abrogation (Phosphorylation of S411 on Beta-2 adrenergic receptor (ADRB2)) of the Beta-2 adrenergic receptor (ADRB2) LIG_PDZ_Class_1 motif - Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (SLC9A3R1) PDZ domain (Also known as DHR or GLGF) interaction

Regulatory Enzymes for switch
Modifying enzymes for residue: S411: G protein-coupled receptor kinase 5 (GRK5)

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: S411 : G protein-coupled receptor kinase 5 (GRK5).

Context
Switch localisation
ELM curated: cytosol, internal side of plasma membrane
Inferred: apical plasma membrane
References

(1) A kinase-regulated PDZ-domain interaction controls endocytic sorting of the beta2-adrenergic receptor.
Cao et al. Nature (1999)

See also

Other switches involving participants
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (SLC9A3R1) - 5 more (view)

Other switches involving interfaces
PDZ domain (Also known as DHR or GLGF) - 45 more (view)
LIG_PDZ_Class_1 - 41 more (view)


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