Switch #: SWTI000207

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of S443 in the PDZ-binding motif of Inward rectifier potassium channel 4 (KCNJ4) by inhibits its interaction with the Disks large homolog 4 (DLG4) protein.

Participants:
(1) Inward rectifier potassium channel 4 (KCNJ4)
(2) Disks large homolog 4 (DLG4)

(1) Binding of the inward rectifier K+ channel Kir 2.3 to PSD-95 is regulated by protein kinase A phosphorylation.
Cohen et al. Neuron (1996)

Other switches involving participants
Disks large homolog 4 (DLG4) - 7 more (view)

Other switches involving interfaces
PDZ domain (Also known as DHR or GLGF) - 45 more (view)
LIG_PDZ_Class_1 - 41 more (view)