Interaction #1 APPL1 - OCRL
(1) ELM:LIG_RhoGAP_OCRL_1 motif (403SFQQRHESLRPAA415) in DCC-interacting protein 13-alpha (APPL1)
(2) RhoGAP domain (735-878) in Inositol polyphosphate 5-phosphatase OCRL-1 (OCRL)
PTM-dependent Abrogation (Phosphorylation of S410 on DCC-interacting protein 13-alpha (APPL1)) of the DCC-interacting protein 13-alpha (APPL1) LIG_RhoGAP_OCRL_1 motif - Inositol polyphosphate 5-phosphatase OCRL-1 (OCRL) RhoGAP domain interaction
Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: S410 : cAMP-dependent protein kinase catalytic subunit alpha (PRKACA).
Affinity : S410: 43.1 µM, pS410: N.D. µM
(1) A role of the Lowe syndrome protein OCRL in early steps of the endocytic pathway.
Other switches involving participants