Switch #: SWTI000206

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of S410 in the RhoGAP-binding motif of DCC-interacting protein 13-alpha (APPL1) inhibits its interaction with Inositol polyphosphate 5-phosphatase OCRL-1 (OCRL).

Participants:
(1) DCC-interacting protein 13-alpha (APPL1)
(2) Inositol polyphosphate 5-phosphatase OCRL-1 (OCRL)

(1) A role of the Lowe syndrome protein OCRL in early steps of the endocytic pathway.
Erdmann et al. Dev. Cell (2007)

(2) Recognition of the F&H motif by the Lowe syndrome protein OCRL.
Pirruccello et al. Nat. Struct. Mol. Biol. (2011)

Other switches involving participants
DCC-interacting protein 13-alpha (APPL1) - 1 more (view)
Inositol polyphosphate 5-phosphatase OCRL-1 (OCRL) - 1 more (view)

Other switches involving interfaces
ELM:LIG_RhoGAP_OCRL_1 - 1 more (view)
RhoGAP domain - 1 more (view)