switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Hide inferred Group Index Colouring Info Filtered: UNIPROT:P27986 (13 hits) x

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Curated inferred

x Index

Epidermal growth factor receptor	Hepatocyte growth factor receptor	Insulin receptor
Platelet-derived growth factor receptor beta	Receptor tyrosine-protein kinase erbB-4

Motif

Protein

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Information

Evidence

Epidermal growth factor receptor - EGFR - Homo sapiens
LIG_SH2_STAT5	GAB1_HUMAN	472	475	Binary	Physicochemical compatibility	Phosphorylation of Y472 in the SH2-binding motif of GRB2-associated-binding protein 1 (GAB1) induces binding to Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1).	details	Inferred
LIG_SH2_STAT5	GAB1_HUMAN	472	475	Binary	Physicochemical compatibility	Phosphorylation of Y472 in the SH2-binding motif of GRB2-associated-binding protein 1 (GAB1) induces binding to Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1).	details	Inferred
LIG_SH2_STAT5	GAB1_HUMAN	447	450	Binary	Physicochemical compatibility	Phosphorylation of Y447 in the SH2-binding motif of GRB2-associated-binding protein 1 (GAB1) induces binding to Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1).	details	Inferred
LIG_SH2_STAT5	GAB1_HUMAN	447	450	Binary	Physicochemical compatibility	Phosphorylation of Y447 in the SH2-binding motif of GRB2-associated-binding protein 1 (GAB1) induces binding to Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1).	details	Inferred
Hepatocyte growth factor receptor - MET - Homo sapiens
LIG_SH2_STAT5	GAB1_HUMAN	472	475	Binary	Physicochemical compatibility	Phosphorylation of Y472 in the SH2-binding motif of GRB2-associated-binding protein 1 (GAB1) induces binding to Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1).	details	Inferred
LIG_SH2_STAT5	GAB1_HUMAN	447	450	Binary	Physicochemical compatibility	Phosphorylation of Y447 in the SH2-binding motif of GRB2-associated-binding protein 1 (GAB1) induces binding to Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1).	details	Inferred
Insulin receptor - INSR - Homo sapiens
LIG_SH2_STAT5	GAB1_HUMAN	472	475	Binary	Physicochemical compatibility	Phosphorylation of Y472 in the SH2-binding motif of GRB2-associated-binding protein 1 (GAB1) induces binding to Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1).	details	Inferred
LIG_SH2_STAT5	GAB1_HUMAN	472	475	Binary	Physicochemical compatibility	Phosphorylation of Y472 in the SH2-binding motif of GRB2-associated-binding protein 1 (GAB1) induces binding to Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1).	details	Inferred
LIG_SH2_STAT5	GAB1_HUMAN	447	450	Binary	Physicochemical compatibility	Phosphorylation of Y447 in the SH2-binding motif of GRB2-associated-binding protein 1 (GAB1) induces binding to Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1).	details	Inferred
LIG_SH2_STAT5	GAB1_HUMAN	447	450	Binary	Physicochemical compatibility	Phosphorylation of Y447 in the SH2-binding motif of GRB2-associated-binding protein 1 (GAB1) induces binding to Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1).	details	Inferred
Platelet-derived growth factor receptor beta - PDGFRB - Homo sapiens
LIG_SH2_IIA	PGFRB_HUMAN	751	755	Binary	Physicochemical compatibility	Phosphorylation of Y751 in the SH2-binding motif of Platelet-derived growth factor receptor beta (PDGFRB) induces binding to the Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) protein.	details	Inferred
LIG_SH2_IIA	PGFRB_HUMAN	751	755	Binary	Physicochemical compatibility	Phosphorylation of Y751 in the SH2-binding motif of Platelet-derived growth factor receptor beta (PDGFRB) induces binding to the Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) protein.	details	Inferred
Receptor tyrosine-protein kinase erbB-4 - ERBB4 - Homo sapiens
LIG_SH2_STAT5	ERBB4_HUMAN	1056	1059	Specificity	Altered binding specificity	Phosphorylation-dependent binding of Receptor tyrosine-protein kinase erbB-4 (ERBB4) to the SH2 domains of Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) results in signaling activation, while binding to the WW domains of E3 ubiquitin-protein ligase Itchy homolog (ITCH) to unphopshorylated ERBB4 results in ubiquitylation, endocytosis and ultimately degradation of ERBB4.	details	Inferred