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| Motif | Protein | Start | End | Switch Type | Switch Subtype | Switch description | Information | Evidence |
CK2 subfamily | ||||||||
| LIG_Clathr_ClatBox_1 | AMPH_HUMAN | 351 | 355 | Binary | Physicochemical compatibility | Phosphorylation of T350 adjacent to the clathrin-binding motif of Amphiphysin (AMPH) by CK2 subfamily inhibits binding to the Clathrin heavy chain 1 (CLTC). A second clathrin-binding motif in Amphiphysin (AMPH) is regulated in a similar manner (see switch details). Both these motifs cooperate in avidity-based binding to Clathrin heavy chain 1 (CLTC) (see switch details). | Curated | |
| LIG_Clathr_ClatBox_2 | AMPH_HUMAN | 380 | 385 | Binary | Physicochemical compatibility | Phosphorylation of T387 adjacent to the clathrin-binding motif of Amphiphysin (AMPH) by CK2 subfamily inhibits binding to the Clathrin heavy chain 1 (CLTC). A second clathrin-binding motif in Amphiphysin (AMPH) is regulated in a similar manner (see switch details). Both these motifs cooperate in avidity-based binding to Clathrin heavy chain 1 (CLTC) (see switch details). | Curated | |
Casein kinase II subunit alpha - CSNK2A1 - Homo sapiens | ||||||||
| LIG_Clathr_ClatBox_1 | AMPH_HUMAN | 351 | 355 | Binary | Physicochemical compatibility | Phosphorylation of T350 adjacent to the clathrin-binding motif of Amphiphysin (AMPH) by CK2 subfamily inhibits binding to the Clathrin heavy chain 1 (CLTC). A second clathrin-binding motif in Amphiphysin (AMPH) is regulated in a similar manner (see switch details). Both these motifs cooperate in avidity-based binding to Clathrin heavy chain 1 (CLTC) (see switch details). | Inferred | |
| LIG_Clathr_ClatBox_2 | AMPH_HUMAN | 380 | 385 | Binary | Physicochemical compatibility | Phosphorylation of T387 adjacent to the clathrin-binding motif of Amphiphysin (AMPH) by CK2 subfamily inhibits binding to the Clathrin heavy chain 1 (CLTC). A second clathrin-binding motif in Amphiphysin (AMPH) is regulated in a similar manner (see switch details). Both these motifs cooperate in avidity-based binding to Clathrin heavy chain 1 (CLTC) (see switch details). | Inferred | |