switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Group Index Colouring Info Filtered: UNIPROT:P10912 (2 hits) x

x Coloured by switch type.

Domain hiding	Altered binding specificity	Motif hiding	Composite binding site formation
Uncategorised	Rheostatic	Allostery	Avidity-sensing
Physicochemical compatibility	Pre-translational	Competition

x Index

Protein

Start

End

Switch Type

Switch Subtype

Switch Description

Information

LIG_SH2_IIA -
GHR_HUMAN	591	600	Binary	Physicochemical compatibility	Phosphorylation of Y595 in the SH2-binding motif of Growth hormone receptor (GHR) induces binding to the Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) protein.	details
LIG_SH2_III -
GHR_HUMAN	428	444	Binary	Physicochemical compatibility	Phosphorylation of Y436 in the SH2-binding motif of Growth hormone receptor (GHR) induces binding to the Signal transducer and activator of transcription 5B (STAT5B) protein.	details