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| Motif | Protein | Start | End | Switch Type | Switch Subtype | Switch description | Information | Evidence |
Endocytosis (KEGG - hsa04144) | ||||||||
| LIG_TKB | EGFR_HUMAN | 1069 | 1074 | Binary | Physicochemical compatibility | Phosphorylation of Y1069 in Epidermal growth factor receptor (EGFR) is necessary for binding to the TKB domain of E3 ubiquitin-protein ligase CBL (CBL). | Inferred | |
| LIG_TKB | EGFR_HUMAN | 1069 | 1074 | Cumulative | Rheostatic | While phosphorylation of Y1069 induces binding, additional phosphorylation of S1070 and S1071 in the TKB-binding motif of Epidermal growth factor receptor (EGFR) gradually lowers its binding affinity for E3 ubiquitin-protein ligase CBL (CBL). | Inferred | |
ErbB signaling pathway (KEGG - hsa04012) | ||||||||
| LIG_TKB | EGFR_HUMAN | 1069 | 1074 | Binary | Physicochemical compatibility | Phosphorylation of Y1069 in Epidermal growth factor receptor (EGFR) is necessary for binding to the TKB domain of E3 ubiquitin-protein ligase CBL (CBL). | Inferred | |
| LIG_TKB | EGFR_HUMAN | 1069 | 1074 | Cumulative | Rheostatic | While phosphorylation of Y1069 induces binding, additional phosphorylation of S1070 and S1071 in the TKB-binding motif of Epidermal growth factor receptor (EGFR) gradually lowers its binding affinity for E3 ubiquitin-protein ligase CBL (CBL). | Inferred | |
Jak-STAT signaling pathway (KEGG - hsa04630) | ||||||||
| LIG_TKB | SPY2_HUMAN | 55 | 60 | Binary | Physicochemical compatibility | Phosphorylation of Y55 in Protein sprouty homolog 2 (SPRY2) is necessary for binding to the TKB domain of E3 ubiquitin-protein ligase CBL (CBL). | Inferred | |
| LIG_TKB | SPY2_HUMAN | 55 | 60 | Cumulative | Rheostatic | While phosphorylation of Y55 induces binding, additional phosphorylation of T56 in the TKB-binding motif of Protein sprouty homolog 2 (SPRY2) lowers its binding affinity for E3 ubiquitin-protein ligase CBL (CBL). | Inferred | |