switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Hide inferred Group Index Colouring Info Filtered: PFAM:PF00179 (5 hits) x

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Curated inferred

x Index

RNA transport

Ubiquitin mediated proteolysis

Motif

Protein

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Information

Evidence

RNA transport (KEGG - hsa03013)
MOD_SUMO	PML_HUMAN	159	162	Uncategorised	Uncategorised	Sumoylation of K160 induces binding to the Protein PML (PML) protein. SUMO-modified forms of PML are essential for the recruitment of Protein PML (PML) to PML nuclear bodies.	details	Inferred
MOD_SUMO	PML_HUMAN	159	162	Uncategorised	Uncategorised	Sumoylation of K160 induces binding to the Protein PML (PML) protein. SUMO-modified forms of PML are essential for the recruitment of Death domain-associated protein 6 (DAXX) to PML nuclear bodies.	details	Inferred
Ubiquitin mediated proteolysis (KEGG - hsa04120)
MOD_SUMO	PML_HUMAN	489	492	Binary	Pre‑translational	Alternative splicing removes the SUMO motif of Protein PML (PML), abrogating binding to SUMO-conjugating enzyme UBC9 (UBE2I). The study identified a major sumoylation site within the nuclear localisation signal (NLS) of PML. Although they did not determine whether the lysine residue regulates the NLS, they found that sumoylation was not necessary for nuclear localisation and that SUMO-modification only occurs in the nucleus.	details	Inferred
MOD_SUMO	PML_HUMAN	159	162	Uncategorised	Uncategorised	Sumoylation of K160 induces binding to the Protein PML (PML) protein. SUMO-modified forms of PML are essential for the recruitment of Protein PML (PML) to PML nuclear bodies.	details	Inferred
MOD_SUMO	PML_HUMAN	159	162	Uncategorised	Uncategorised	Sumoylation of K160 induces binding to the Protein PML (PML) protein. SUMO-modified forms of PML are essential for the recruitment of Death domain-associated protein 6 (DAXX) to PML nuclear bodies.	details	Inferred