switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Hide inferred Group Index Colouring Info Filtered: UNIPROT:P06213 (5 hits) x

x Coloured by: Pathway evidence source
Curated inferred

x Index

Aldosterone-regulated sodium reabsorption	HIF-1 signaling pathway	Insulin signaling pathway
PI3K-Akt signaling pathway

Motif

Protein

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Information

Evidence

Aldosterone-regulated sodium reabsorption (KEGG - hsa04960)
LIG_SH2_STAT5	INSR_HUMAN	1361	1364	Specificity	Domain hiding	PIP3 (1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate), a product of PI3-kinase, binds to the SH2 domains of PI3K (Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)) and thereby blocks its interaction with tyrosine-phosphorylated SH2 motif containing proteins.	details	Inferred
HIF-1 signaling pathway (KEGG - hsa04066)
LIG_SH2_STAT5	INSR_HUMAN	1361	1364	Specificity	Domain hiding	PIP3 (1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate), a product of PI3-kinase, binds to the SH2 domains of PI3K (Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)) and thereby blocks its interaction with tyrosine-phosphorylated SH2 motif containing proteins.	details	Inferred
Insulin signaling pathway (KEGG - hsa04910)
LIG_PTB_Phospho_1	INSR_HUMAN	993	999	Binary	Physicochemical compatibility	Phosphorylation of Y999 in the PTB-binding motif of Insulin receptor (INSR) induces binding to the SHC-transforming protein 1 (SHC1) protein.	details	Inferred
LIG_SH2_STAT5	INSR_HUMAN	1361	1364	Specificity	Domain hiding	PIP3 (1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate), a product of PI3-kinase, binds to the SH2 domains of PI3K (Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)) and thereby blocks its interaction with tyrosine-phosphorylated SH2 motif containing proteins.	details	Inferred
PI3K-Akt signaling pathway (KEGG - hsa04151)
LIG_SH2_STAT5	INSR_HUMAN	1361	1364	Specificity	Domain hiding	PIP3 (1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate), a product of PI3-kinase, binds to the SH2 domains of PI3K (Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)) and thereby blocks its interaction with tyrosine-phosphorylated SH2 motif containing proteins.	details	Inferred