switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Hide inferred Group Index Colouring Info Filtered: UNIPROT:P20248 (6 hits) x

x Coloured by: Pathway evidence source
Curated inferred

x Index

Cell cycle

S Phase

Motif

Protein

Start

End

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Information

Evidence

Cell cycle (KEGG - hsa04110)
DOC_CYCLIN_1	CDN1B_HUMAN	30	33	Specificity	Domain hiding	Binding of the CDK-cyclin inhibitor p27 (Cyclin-dependent kinase inhibitor 1B (CDKN1B)) blocks the substrate recruitment site on Cyclin-A2 (CCNA2).	details	Curated
DOC_CYCLIN_1	CDC6_HUMAN	94	98	Specificity	Domain hiding	Binding of the CDK-cyclin inhibitor p27 (Cyclin-dependent kinase inhibitor 1B (CDKN1B)) blocks the substrate recruitment site on Cyclin-A2 (CCNA2).	details	Curated
DOC_CYCLIN_1	RB_HUMAN	873	877	Specificity	Competition	The docking sites for PP1 (e.g. Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PPP1CA)) and Cdk-Cyclins (e.g. Cyclin-A2 (CCNA2)) on Retinoblastoma-associated protein (RB1) overlap, which makes their binding to RB1 mutually exclusive. Hypophosphorylated RB1 blocks E2F-dependent transcription, while hyperphosphorylation inactivates RB1 as a repressor, thereby promoting cell cycle progression.	details	Inferred
DOC_PP1	RB_HUMAN	872	878	Specificity	Competition	The docking sites for PP1 (e.g. Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PPP1CA)) and Cdk-Cyclins (e.g. Cyclin-A2 (CCNA2)) on Retinoblastoma-associated protein (RB1) overlap, which makes their binding to RB1 mutually exclusive. Hypophosphorylated RB1 blocks E2F-dependent transcription, while hyperphosphorylation inactivates RB1 as a repressor, thereby promoting cell cycle progression.	details	Inferred
S Phase (Reactome - 69242)
DOC_CYCLIN_1	CDN1B_HUMAN	30	33	Specificity	Domain hiding	Binding of the CDK-cyclin inhibitor p27 (Cyclin-dependent kinase inhibitor 1B (CDKN1B)) blocks the substrate recruitment site on Cyclin-A2 (CCNA2).	details	Curated
DOC_CYCLIN_1	CDC6_HUMAN	94	98	Specificity	Domain hiding	Binding of the CDK-cyclin inhibitor p27 (Cyclin-dependent kinase inhibitor 1B (CDKN1B)) blocks the substrate recruitment site on Cyclin-A2 (CCNA2).	details	Curated