Motif | Protein | Start | End | Switch Type | Switch Subtype | Switch description | Information | Evidence |
Jak-STAT signaling pathway (KEGG - hsa04630) | ||||||||
LIG_SH2_IIA | IL4RA_HUMAN | 706 | 721 | Binary | Physicochemical compatibility | Phosphorylation of Y713 in the SH2-binding motif of Interleukin-4 receptor subunit alpha (IL4R) induces binding to the Tyrosine-protein phosphatase non-receptor type 6 (PTPN6) protein. | Inferred | |
Natural killer cell mediated cytotoxicity (KEGG - hsa04650) | ||||||||
LIG_TYR_ITIM | KI3L2_HUMAN | 396 | 401 | Binary | Physicochemical compatibility | Phosphorylation of Y398 in the ITIM motif of Killer cell immunoglobulin-like receptor 3DL2 (KIR3DL2) induces binding of Tyrosine-protein phosphatase non-receptor type 6 (PTPN6) via one of its SH2 domains. | Inferred |