switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Hide inferred Group Index Colouring Info Filtered: UNIPROT:P29350 (2 hits) x

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Curated inferred

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Information

Evidence

Jak-STAT signaling pathway (KEGG - hsa04630)
LIG_SH2_IIA	IL4RA_HUMAN	706	721	Binary	Physicochemical compatibility	Phosphorylation of Y713 in the SH2-binding motif of Interleukin-4 receptor subunit alpha (IL4R) induces binding to the Tyrosine-protein phosphatase non-receptor type 6 (PTPN6) protein.	details	Inferred
Natural killer cell mediated cytotoxicity (KEGG - hsa04650)
LIG_TYR_ITIM	KI3L2_HUMAN	396	401	Binary	Physicochemical compatibility	Phosphorylation of Y398 in the ITIM motif of Killer cell immunoglobulin-like receptor 3DL2 (KIR3DL2) induces binding of Tyrosine-protein phosphatase non-receptor type 6 (PTPN6) via one of its SH2 domains.	details	Inferred