switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Hide inferred Group Index Colouring Info Filtered: UNIPROT:P35568 (5 hits) x

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Curated inferred

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Motif

Protein

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Information

Evidence

Neurotrophin signaling pathway (KEGG - hsa04722)
LIG_14-3-3_3	IRS1_HUMAN	371	376	Avidity‑sensing		Phosphorylation of two 14-3-3-binding motifs in Insulin receptor substrate 1 (IRS1) induces high-avidity binding to dimeric 14-3-3 protein epsilon (YWHAE).	details	Inferred
LIG_14-3-3_3	IRS1_HUMAN	638	643	Avidity‑sensing		Phosphorylation of two 14-3-3-binding motifs in Insulin receptor substrate 1 (IRS1) induces high-avidity binding to dimeric 14-3-3 protein epsilon (YWHAE).	details	Inferred
PI3K-Akt signaling pathway (KEGG - hsa04151)
LIG_PTB_Phospho_1	IL4RA_HUMAN	491	497	Binary	Physicochemical compatibility	Phosphorylation of Y497 in the PTB-binding motif of Interleukin-4 receptor subunit alpha (IL4R) induces binding to the Insulin receptor substrate 1 (IRS1) protein.	details	Inferred
LIG_14-3-3_3	IRS1_HUMAN	371	376	Avidity‑sensing		Phosphorylation of two 14-3-3-binding motifs in Insulin receptor substrate 1 (IRS1) induces high-avidity binding to dimeric 14-3-3 protein epsilon (YWHAE).	details	Inferred
LIG_14-3-3_3	IRS1_HUMAN	638	643	Avidity‑sensing		Phosphorylation of two 14-3-3-binding motifs in Insulin receptor substrate 1 (IRS1) induces high-avidity binding to dimeric 14-3-3 protein epsilon (YWHAE).	details	Inferred