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Filtered:
UNIPROT:P42229 (5 hits)
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Curated
inferred
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Index
ErbB signaling pathway
Growth hormone receptor signaling
Jak-STAT signaling pathway
Motif
Protein
Start
End
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Information
Evidence
ErbB signaling pathway
(
KEGG - hsa04012
)
LIG_SH2_III
STA5A_HUMAN
686
702
Binary
Physicochemical compatibility
Phosphorylation of Y694 in the SH2-binding motif of
Signal transducer and activator of transcription 5A (STAT5A)
induces binding to the
Signal transducer and activator of transcription 5B (STAT5B)
protein.
details
Curated
Growth hormone receptor signaling
(
Reactome - 982772
)
LIG_SH2_III
STA5A_HUMAN
686
702
Binary
Physicochemical compatibility
Phosphorylation of Y694 in the SH2-binding motif of
Signal transducer and activator of transcription 5A (STAT5A)
induces binding to the
Signal transducer and activator of transcription 5B (STAT5B)
protein.
details
Curated
Jak-STAT signaling pathway
(
KEGG - hsa04630
)
LIG_SH2_III
IL2RB_HUMAN
531
540
Binary
Physicochemical compatibility
Phosphorylation of Y536 in the SH2-binding motif of
Interleukin-2 receptor subunit beta (IL2RB)
induces binding to the
Signal transducer and activator of transcription 5A (STAT5A)
protein.
details
Inferred
LIG_SH2_III
STA5A_HUMAN
686
702
Binary
Physicochemical compatibility
Phosphorylation of Y694 in the SH2-binding motif of
Signal transducer and activator of transcription 5A (STAT5A)
induces binding to the
Signal transducer and activator of transcription 5B (STAT5B)
protein.
details
Curated
LIG_SH2_STAT5
PRLR_HUMAN
342
345
Binary
Pre‑translational
Alternative Splicing removes the degron motif of
Prolactin receptor (PRLR)
, abrogating binding to
Signal transducer and activator of transcription 5A (STAT5A)
. The PRLR S1a (
Isoform Short form 1a of Prolactin receptor (PRLR)
) and S1b and (
Isoform Short form 1b of Prolactin receptor (PRLR)
) isoforms were unable to mediate the transcriptional activation of the beta-casein promoter via the JAK-STAT5 pathway. Therefore these two splice variants act as dominant negatives on the full-length version LF (
Isoform 1 of Prolactin receptor (PRLR)
). Another study showed that different splice variants of heterodimers (e.g. LF/S1a, LF/S1b) that were able to induce JAK2 phosphorylation but not further signalling events due to lack of STAT recruitment (Qazi et al. (2006)
(here)
).
details
Inferred
