Switch #: SWTI000626

Switch type: Binary

Switch subtype: Pre-translational

Description:
Alternative Splicing removes the degron motif of Prolactin receptor (PRLR), abrogating binding to Signal transducer and activator of transcription 5A (STAT5A). The PRLR S1a (Isoform Short form 1a of Prolactin receptor (PRLR)) and S1b and (Isoform Short form 1b of Prolactin receptor (PRLR)) isoforms were unable to mediate the transcriptional activation of the beta-casein promoter via the JAK-STAT5 pathway. Therefore these two splice variants act as dominant negatives on the full-length version LF (Isoform 1 of Prolactin receptor (PRLR)). Another study showed that different splice variants of heterodimers (e.g. LF/S1a, LF/S1b) that were able to induce JAK2 phosphorylation but not further signalling events due to lack of STAT recruitment (Qazi et al. (2006) (here)).

Participants:
(1) Prolactin receptor (PRLR)
(2) Signal transducer and activator of transcription 5A (STAT5A)

(1) Isolation and characterization of two novel forms of the human prolactin receptor generated by alternative splicing of a newly identified exon 11.
Hu et al. J. Biol. Chem. (2001)

Other switches involving participants
Prolactin receptor (PRLR) - 2 more (view)
Signal transducer and activator of transcription 5A (STAT5A) - 3 more (view)

Other switches involving interfaces
LIG_SH2_STAT5 - 7 more (view)
SH2 domain - 140 more (view)