switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Hide inferred Group Index Colouring Info Filtered: UNIPROT:Q00987 (6 hits) x

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Curated inferred

x Index

Cell cycle

p53 signaling pathway

p53-Dependent G1/S DNA damage checkpoint

Motif

Protein

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Information

Evidence

Cell cycle (KEGG - hsa04110)
DEG_MDM2_1	P53_HUMAN	19	26	Binary	Physicochemical compatibility	Phosphorylation of Cellular tumor antigen p53 (TP53) on T18 (in vitro by Casein kinase I subfamily, requiring prior phosphorylation of S15) inhibits its binding to E3 ubiquitin-protein ligase Mdm2 (MDM2). In vivo, T18 is phosphorylated in response to DNA damage.	details	Curated
DEG_MDM2_1	P53_HUMAN	19	26	Binary	Pre‑translational	Alternative promoter usage and alternative splicing removes the E3 ubiquitin ligase MDM2-binding motif of Cellular tumor antigen p53 (TP53), abrogating binding to E3 ubiquitin-protein ligase Mdm2 (MDM2). The splice variant without this motif is resistant to MDM2-mediated degradation, leading to a longer half-life.	details	Curated
p53 signaling pathway (KEGG - hsa04115)
DEG_MDM2_1	P53_HUMAN	19	26	Binary	Physicochemical compatibility	Phosphorylation of Cellular tumor antigen p53 (TP53) on T18 (in vitro by Casein kinase I subfamily, requiring prior phosphorylation of S15) inhibits its binding to E3 ubiquitin-protein ligase Mdm2 (MDM2). In vivo, T18 is phosphorylated in response to DNA damage.	details	Curated
DEG_MDM2_1	P53_HUMAN	19	26	Binary	Pre‑translational	Alternative promoter usage and alternative splicing removes the E3 ubiquitin ligase MDM2-binding motif of Cellular tumor antigen p53 (TP53), abrogating binding to E3 ubiquitin-protein ligase Mdm2 (MDM2). The splice variant without this motif is resistant to MDM2-mediated degradation, leading to a longer half-life.	details	Curated
p53-Dependent G1/S DNA damage checkpoint (Reactome - 69580)
DEG_MDM2_1	P53_HUMAN	19	26	Binary	Physicochemical compatibility	Phosphorylation of Cellular tumor antigen p53 (TP53) on T18 (in vitro by Casein kinase I subfamily, requiring prior phosphorylation of S15) inhibits its binding to E3 ubiquitin-protein ligase Mdm2 (MDM2). In vivo, T18 is phosphorylated in response to DNA damage.	details	Curated
DEG_MDM2_1	P53_HUMAN	19	26	Binary	Pre‑translational	Alternative promoter usage and alternative splicing removes the E3 ubiquitin ligase MDM2-binding motif of Cellular tumor antigen p53 (TP53), abrogating binding to E3 ubiquitin-protein ligase Mdm2 (MDM2). The splice variant without this motif is resistant to MDM2-mediated degradation, leading to a longer half-life.	details	Curated