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Group by :Switch typeMotif classProteinEnzymePathway         Hide inferred   Group Index    Colouring Info              Filtered: UNIPROT:Q00987 (6 hits) x


x  Coloured by: Pathway evidence source
          Curated          inferred


x  Index
Cell cyclep53 signaling pathwayp53-Dependent G1/S DNA damage checkpoint


MotifProteinStartEndSwitch TypeSwitch SubtypeSwitch descriptionInformationEvidence

Cell cycle (KEGG - hsa04110)
DEG_MDM2_1 P53_HUMAN1926BinaryPhysicochemical compatibilityPhosphorylation of Cellular tumor antigen p53 (TP53) on T18 (in vitro by Casein kinase I subfamily, requiring prior phosphorylation of S15) inhibits its binding to E3 ubiquitin-protein ligase Mdm2 (MDM2). In vivo, T18 is phosphorylated in response to DNA damage.
details
Curated
DEG_MDM2_1 P53_HUMAN1926BinaryPre‑translationalAlternative promoter usage and alternative splicing removes the E3 ubiquitin ligase MDM2-binding motif of Cellular tumor antigen p53 (TP53), abrogating binding to E3 ubiquitin-protein ligase Mdm2 (MDM2). The splice variant without this motif is resistant to MDM2-mediated degradation, leading to a longer half-life.
details
Curated

p53 signaling pathway (KEGG - hsa04115)
DEG_MDM2_1 P53_HUMAN1926BinaryPhysicochemical compatibilityPhosphorylation of Cellular tumor antigen p53 (TP53) on T18 (in vitro by Casein kinase I subfamily, requiring prior phosphorylation of S15) inhibits its binding to E3 ubiquitin-protein ligase Mdm2 (MDM2). In vivo, T18 is phosphorylated in response to DNA damage.
details
Curated
DEG_MDM2_1 P53_HUMAN1926BinaryPre‑translationalAlternative promoter usage and alternative splicing removes the E3 ubiquitin ligase MDM2-binding motif of Cellular tumor antigen p53 (TP53), abrogating binding to E3 ubiquitin-protein ligase Mdm2 (MDM2). The splice variant without this motif is resistant to MDM2-mediated degradation, leading to a longer half-life.
details
Curated

p53-Dependent G1/S DNA damage checkpoint (Reactome - 69580)
DEG_MDM2_1 P53_HUMAN1926BinaryPhysicochemical compatibilityPhosphorylation of Cellular tumor antigen p53 (TP53) on T18 (in vitro by Casein kinase I subfamily, requiring prior phosphorylation of S15) inhibits its binding to E3 ubiquitin-protein ligase Mdm2 (MDM2). In vivo, T18 is phosphorylated in response to DNA damage.
details
Curated
DEG_MDM2_1 P53_HUMAN1926BinaryPre‑translationalAlternative promoter usage and alternative splicing removes the E3 ubiquitin ligase MDM2-binding motif of Cellular tumor antigen p53 (TP53), abrogating binding to E3 ubiquitin-protein ligase Mdm2 (MDM2). The splice variant without this motif is resistant to MDM2-mediated degradation, leading to a longer half-life.
details
Curated
           
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