switches
.ELM
About
Help
Definitions
Submit
Search
Analyse
Browse
Home
Group by :
Switch type
Motif class
Protein
Enzyme
Pathway
         
Hide inferred
  
Group Index
  
Colouring Info
             
Filtered:
UNIPROT:Q06124 (4 hits)
x
submit
x
  
Coloured by:
Pathway evidence source
        
 
Curated        
 
inferred
x
  
Index
Jak-STAT signaling pathway
Neurotrophin signaling pathway
Motif
Protein
Start
End
Switch Type
Switch Subtype
Switch description
Information
Evidence
Jak-STAT signaling pathway
(
KEGG - hsa04630
)
LIG_SH2_IIA
GHR_HUMAN
591
600
Binary
Physicochemical compatibility
Phosphorylation of Y595 in the SH2-binding motif of
Growth hormone receptor (GHR)
induces binding to the
Tyrosine-protein phosphatase non-receptor type 11 (PTPN11)
protein.
details
Inferred
LIG_SH2_IIA
IL4RA_HUMAN
706
721
Binary
Physicochemical compatibility
Phosphorylation of Y713 in the SH2-binding motif of
Interleukin-4 receptor subunit alpha (IL4R)
induces binding to the
Tyrosine-protein phosphatase non-receptor type 11 (PTPN11)
protein.
details
Inferred
Neurotrophin signaling pathway
(
KEGG - hsa04722
)
LIG_SH2_IIA
FRS2_HUMAN
431
440
Binary
Physicochemical compatibility
Phosphorylation of Y436 in the SH2-binding motif of
Fibroblast growth factor receptor substrate 2 (FRS2)
induces binding to the
Tyrosine-protein phosphatase non-receptor type 11 (PTPN11)
protein.
details
Inferred
LIG_SH2_IIA
FRS2_HUMAN
465
475
Binary
Physicochemical compatibility
Phosphorylation of Y471 in the SH2-binding motif of
Fibroblast growth factor receptor substrate 2 (FRS2)
induces binding to the
Tyrosine-protein phosphatase non-receptor type 11 (PTPN11)
protein.
details
Inferred