switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Hide inferred Group Index Colouring Info Filtered: UNIPROT:Q8WU20 (6 hits) x

x Coloured by: Pathway evidence source
Curated inferred

x Index

Neurotrophin signaling pathway

Motif

Protein

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Information

Evidence

Neurotrophin signaling pathway (KEGG - hsa04722)
LIG_SH2_IC	FRS2_HUMAN	191	200	Binary	Physicochemical compatibility	Phosphorylation of Y196 in the SH2-binding motif of Fibroblast growth factor receptor substrate 2 (FRS2) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.	details	Inferred
LIG_SH2_IC	FRS2_HUMAN	301	310	Binary	Physicochemical compatibility	Phosphorylation of Y306 in the SH2-binding motif of Fibroblast growth factor receptor substrate 2 (FRS2) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.	details	Inferred
LIG_SH2_IC	FRS2_HUMAN	345	355	Binary	Physicochemical compatibility	Phosphorylation of Y349 in the SH2-binding motif of Fibroblast growth factor receptor substrate 2 (FRS2) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.	details	Inferred
LIG_SH2_IC	FRS2_HUMAN	385	395	Binary	Physicochemical compatibility	Phosphorylation of Y392 in the SH2-binding motif of Fibroblast growth factor receptor substrate 2 (FRS2) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.	details	Inferred
LIG_SH2_IIA	FRS2_HUMAN	431	440	Binary	Physicochemical compatibility	Phosphorylation of Y436 in the SH2-binding motif of Fibroblast growth factor receptor substrate 2 (FRS2) induces binding to the Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) protein.	details	Inferred
LIG_SH2_IIA	FRS2_HUMAN	465	475	Binary	Physicochemical compatibility	Phosphorylation of Y471 in the SH2-binding motif of Fibroblast growth factor receptor substrate 2 (FRS2) induces binding to the Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) protein.	details	Inferred