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| Domain hiding | Altered binding specificity | Motif hiding | Composite binding site formation |
| Uncategorised | Rheostatic | Allostery | Avidity-sensing |
| Physicochemical compatibility | Pre-translational | Competition |
| Motif | Start | End | Switch Type | Switch Subtype | Switch Description | Information |
Epidermal growth factor receptor - EGFR - Homo sapiens | |||||||
| LIG_TKB | 1069 | 1074 | Binary | Physicochemical compatibility | Phosphorylation of Y1069 in Epidermal growth factor receptor (EGFR) is necessary for binding to the TKB domain of E3 ubiquitin-protein ligase CBL (CBL). | ||
| LIG_TKB | 1069 | 1074 | Cumulative | Rheostatic | While phosphorylation of Y1069 induces binding, additional phosphorylation of S1070 and S1071 in the TKB-binding motif of Epidermal growth factor receptor (EGFR) gradually lowers its binding affinity for E3 ubiquitin-protein ligase CBL (CBL). | ||
Protein sprouty homolog 2 - SPRY2 - Homo sapiens | |||||||
| LIG_TKB | 55 | 60 | Binary | Physicochemical compatibility | Phosphorylation of Y55 in Protein sprouty homolog 2 (SPRY2) is necessary for binding to the TKB domain of E3 ubiquitin-protein ligase CBL (CBL). | ||
| LIG_TKB | 55 | 60 | Cumulative | Rheostatic | While phosphorylation of Y55 induces binding, additional phosphorylation of T56 in the TKB-binding motif of Protein sprouty homolog 2 (SPRY2) lowers its binding affinity for E3 ubiquitin-protein ligase CBL (CBL). | ||