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| Domain hiding | Altered binding specificity | Motif hiding | Composite binding site formation |
| Uncategorised | Rheostatic | Allostery | Avidity-sensing |
| Physicochemical compatibility | Pre-translational | Competition |
| 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (Mus) | 5-hydroxytryptamine receptor 4 (Mus) |
| Motif | Start | End | Switch Type | Switch Subtype | Switch Description | Information |
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 - Plcb1 - Mus musculus | |||||||
| LIG_PDZ_Class_1 | 1211 | 1216 | Binary | Pre‑translational | Alternative splicing removes the PDZ-binding motif of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (Plcb1), abrogating binding to Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (Slc9a3r1). Plcb1 does not bind to Slc9a3r2. | ||
5-hydroxytryptamine receptor 4 - Htr4 - Mus musculus | |||||||
| LIG_PDZ_Class_1 | 382 | 387 | Binary | Pre‑translational | Alternative splicing removes the PDZ-binding motif of Isoform 5-HT4(A) of 5-hydroxytryptamine receptor 4 (Htr4), abrogating binding to Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (Slc9a3r1). Isoform 5-HT4(A) of 5-hydroxytryptamine receptor 4 (Htr4) interacts specifically with a protein complex including Slc9a3r1 and Ezrin (Ezr) that might participate in its targeting to specialised subcellular regions, such as microvilli. | ||
| LIG_PDZ_Class_1 | 382 | 387 | Binary | Pre‑translational | Alternative splicing removes the PDZ-binding motif of Isoform 5-HT4(A) of 5-hydroxytryptamine receptor 4 (Htr4), abrogating binding to Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (Slc9a3r1). Isoform 5-HT4(A) of 5-hydroxytryptamine receptor 4 (Htr4) interacts specifically with a protein complex including Slc9a3r1 and Ezrin (Ezr) that might participate in its targeting to specialised subcellular regions, such as microvilli. | ||