Domain hiding |   Altered binding specificity |   Motif hiding |   Composite binding site formation |
  Uncategorised |   Rheostatic |   Allostery |   Avidity-sensing |
  Physicochemical compatibility |   Pre-translational |   Competition |
Protein | Motif | Start | End | Switch description | Information |
Type: Binary Subtype: Pre‑translational | |||||||
Pre-translational mechanisms such as alternative splicing, alternative promoter-usage and/or RNA editing result in inclusion or removal of exons that contain an entire or partial motif. | |||||||
GRM1_RAT | LIG_EVH1_2 | 1152 | 1156 | Alternative splicing removes the EVH1-binding motif of Metabotropic glutamate receptor 1 (Grm1), abrogating binding to Homer protein homolog 1 (Homer1), which is important for spatial targeting of Grm1. | |||
XIRP1_HUMAN | LIG_EVH1_1 | 22 | 26 | Alternative splicing removes the EVH1-binding motif of Xin actin-binding repeat-containing protein 1 (XIRP1), abrogating binding to Protein enabled homolog (ENAH). | |||
XIRP1_HUMAN | LIG_EVH1_1 | 22 | 26 | Alternative splicing removes the EVH1-binding motif of Xin actin-binding repeat-containing protein 1 (XIRP1), abrogating binding to Vasodilator-stimulated phosphoprotein (VASP). |