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Group by :Switch type Motif class Protein Enzyme Pathway Show inferred Group Index Colouring Info Filtered: ELM:DEG_MDM2_1 (1 hits) x

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Curated inferred

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Casein kinase I subfamily
DEG_MDM2_1	P53_HUMAN	19	26	Binary	Physicochemical compatibility	Phosphorylation of Cellular tumor antigen p53 (TP53) on T18 (in vitro by Casein kinase I subfamily, requiring prior phosphorylation of S15) inhibits its binding to E3 ubiquitin-protein ligase Mdm2 (MDM2). In vivo, T18 is phosphorylated in response to DNA damage.	details	Curated