Motif | Protein | Start | End | Switch Type | Switch Subtype | Switch description | Information | Evidence |
Cyclin-dependent protein kinase PHO85 - PHO85 -  Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | ||||||||
TRG_NLS_MonoExtC_3 | PHO4_YEAST | 156 | 161 | Binary | Physicochemical compatibility | Phosphorylation of S152 adjacent to the NLS of Phosphate system positive regulatory protein PHO4 (PHO4) by the Pho80-Pho85 CDK-Cyclin complex inhibits nuclear import this protein by blocking its interaction with Importin subunit beta-3 (PSE1). Upon phosphate starvation, Pho81 inhibits the Pho80-Pho85 complex, leading to translocation of Phosphate system positive regulatory protein PHO4 (PHO4) to the nucleus, where it regulates expression of phosphate-responsive genes. | Curated |