switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Hide inferred Group Index Colouring Info Filtered: ELM:TRG_NLS_MonoExtC_3 (1 hits) x

x Coloured by: Modifier evidence source
Curated inferred

x Index

Motif

Protein

Start

End

Switch Type

Switch Subtype

Switch description

Information

Evidence

Cyclin-dependent protein kinase PHO85 - PHO85 - Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
TRG_NLS_MonoExtC_3	PHO4_YEAST	156	161	Binary	Physicochemical compatibility	Phosphorylation of S152 adjacent to the NLS of Phosphate system positive regulatory protein PHO4 (PHO4) by the Pho80-Pho85 CDK-Cyclin complex inhibits nuclear import this protein by blocking its interaction with Importin subunit beta-3 (PSE1). Upon phosphate starvation, Pho81 inhibits the Pho80-Pho85 complex, leading to translocation of Phosphate system positive regulatory protein PHO4 (PHO4) to the nucleus, where it regulates expression of phosphate-responsive genes.	details	Curated