switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Show inferred Group Index Colouring Info Filtered: PFAM:PF01394 (2 hits) x

x Coloured by: Modifier evidence source
Curated inferred

x Index

Motif

Protein

Start

End

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Information

Evidence

CK2 subfamily
LIG_Clathr_ClatBox_1	AMPH_HUMAN	351	355	Binary	Physicochemical compatibility	Phosphorylation of T350 adjacent to the clathrin-binding motif of Amphiphysin (AMPH) by CK2 subfamily inhibits binding to the Clathrin heavy chain 1 (CLTC). A second clathrin-binding motif in Amphiphysin (AMPH) is regulated in a similar manner (see switch details). Both these motifs cooperate in avidity-based binding to Clathrin heavy chain 1 (CLTC) (see switch details).	details	Curated
LIG_Clathr_ClatBox_2	AMPH_HUMAN	380	385	Binary	Physicochemical compatibility	Phosphorylation of T387 adjacent to the clathrin-binding motif of Amphiphysin (AMPH) by CK2 subfamily inhibits binding to the Clathrin heavy chain 1 (CLTC). A second clathrin-binding motif in Amphiphysin (AMPH) is regulated in a similar manner (see switch details). Both these motifs cooperate in avidity-based binding to Clathrin heavy chain 1 (CLTC) (see switch details).	details	Curated