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PFAM:PF02747 (3 hits)
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Modifier evidence source
Curated
inferred
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Index
PKC subfamily
()
RAC-alpha serine/threonine-protein kinase
cAMP subfamily
()
Motif
Protein
Start
End
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Information
Evidence
PKC subfamily
LIG_PCNA_PIPBox_1
CDN1A_HUMAN
144
153
Binary
Physicochemical compatibility
Phosphorylation of S146 in the PCNA-binding motif of
Cyclin-dependent kinase inhibitor 1 (CDKN1A)
by
PKC subfamily
inhibits binding to
Proliferating cell nuclear antigen (PCNA)
. As a result,
Cyclin-dependent kinase inhibitor 1 (CDKN1A)
no longer inhibits
Proliferating cell nuclear antigen (PCNA)
and blocking of DNA replication is relieved.
details
Curated
cAMP subfamily
LIG_PCNA_PIPBox_1
DPOD3_HUMAN
456
465
Binary
Physicochemical compatibility
Phosphorylation of S458 in the PCNA-binding motif of
DNA polymerase delta subunit 3 (POLD3)
by
cAMP subfamily
reduces the affinity of binding to the
Proliferating cell nuclear antigen (PCNA)
and decreases the processivity of the polymerase complex.
details
Curated
RAC-alpha serine/threonine-protein kinase -
AKT1
-
Homo sapiens
LIG_PCNA_PIPBox_1
CDN1A_HUMAN
144
153
Binary
Physicochemical compatibility
Phosphorylation of T145 in the PCNA-binding motif of
Cyclin-dependent kinase inhibitor 1 (CDKN1A)
by
RAC-alpha serine/threonine-protein kinase (AKT1)
inhibits binding to
Proliferating cell nuclear antigen (PCNA)
. As a result,
Cyclin-dependent kinase inhibitor 1 (CDKN1A)
no longer inhibits
Proliferating cell nuclear antigen (PCNA)
and blocking of DNA replication is relieved.
details
Curated
