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UNIPROT:P01106 (5 hits)
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Index
GSK-3 subfamily
()
Glycogen synthase kinase-3 beta
Mitogen-activated protein kinase 1
Motif
Protein
Start
End
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Information
Evidence
GSK-3 subfamily
LIG_SH3_2
MYC_HUMAN
60
65
Binary
Physicochemical compatibility
Phosphorylation of S62 in the SH3-binding motif of
Myc proto-oncogene protein (MYC)
by
GSK-3 subfamily
disrupts its interaction with
Myc box-dependent-interacting protein 1 (BIN1)
.
details
Curated
Glycogen synthase kinase-3 beta -
GSK3B
-
Homo sapiens
DEG_SCF_FBW7_1
MYC_HUMAN
55
62
Specificity
Altered binding specificity
Phosphorylation of
Myc proto-oncogene protein (MYC)
at S62 by
Mitogen-activated protein kinase 1 (MAPK1)
primes
MYC
for phosphorylation by
Glycogen synthase kinase-3 beta (GSK3B)
, which targets
MYC
to the SCF ubiquitin ligase complex,
F-box/WD repeat-containing protein 7 (FBXW7)
that marks
MYC
for degradation.
details
Curated
Mitogen-activated protein kinase 1 -
MAPK1
-
Homo sapiens
MOD_GSK3_1
MYC_HUMAN
55
62
Binary
Physicochemical compatibility
Phosphorylation of
Myc proto-oncogene protein (MYC)
at S62 primes the protein for phosphorylation at T58 by
Glycogen synthase kinase-3 beta (GSK3B)
.
details
Curated
MOD_GSK3_1
MYC_HUMAN
55
62
Specificity
Altered binding specificity
Phosphorylation of
Myc proto-oncogene protein (MYC)
at S62 by
Mitogen-activated protein kinase 1 (MAPK1)
primes
MYC
for phosphorylation by
Glycogen synthase kinase-3 beta (GSK3B)
, which targets
MYC
to the SCF ubiquitin ligase complex,
F-box/WD repeat-containing protein 7 (FBXW7)
that marks
MYC
for degradation.
details
Curated
DEG_SCF_FBW7_1
MYC_HUMAN
55
62
Specificity
Altered binding specificity
Phosphorylation of
Myc proto-oncogene protein (MYC)
at S62 by
Mitogen-activated protein kinase 1 (MAPK1)
primes
MYC
for phosphorylation by
Glycogen synthase kinase-3 beta (GSK3B)
, which targets
MYC
to the SCF ubiquitin ligase complex,
F-box/WD repeat-containing protein 7 (FBXW7)
that marks
MYC
for degradation.
details
Curated
