Switches.ELM

Switch #:

SWTI000015

Switch type:
Binary

Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Myc proto-oncogene protein (MYC) at S62 primes the protein for phosphorylation at T58 by Glycogen synthase kinase-3 beta (GSK3B).

Participants:
(1) Myc proto-oncogene protein (MYC)
(2) Glycogen synthase kinase-3 beta (GSK3B)

Interactions

Interaction #1 MYC - GSK3B

Interfaces
(1) MOD_GSK3_1 motif (₅₅LLPTPPLS₆₂) in Myc proto-oncogene protein (MYC)
(2) Protein kinase domain_(56-340) in Glycogen synthase kinase-3 beta (GSK3B)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S₆₂ on Myc proto-oncogene protein (MYC)) of the Myc proto-oncogene protein (MYC) MOD_GSK3_1 motif - Glycogen synthase kinase-3 beta (GSK3B) Protein kinase domain interaction

Regulatory Enzymes for switch
Modifying enzymes for residue: S₆₂: Mitogen-activated protein kinase 1 (MAPK1)

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: S₆₂ : Cyclin-dependent kinase 5 (CDK5), Mitogen-activated protein kinase 3 (Mapk3), ERK2, Mitogen-activated protein kinase 8 (MAPK8), Mitogen-activated protein kinase 9 (MAPK9), Mitogen-activated protein kinase 10 (MAPK10), Serine/threonine-protein kinase mTOR (MTOR), Mitogen-activated protein kinase 1 (MAPK1).

Context

References

(1) Phosphorylation by glycogen synthase kinase-3 controls c-myc proteolysis and subnuclear localization.
Gregory et al. J. Biol. Chem. (2003)