Switches.ELM

Switch #:

SWTI000016

Switch type:
Binary

Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Cellular tumor antigen p53 (TP53) at S37 primes the protein for phosphorylation at S33 by Glycogen synthase kinase-3 beta (GSK3B).

Participants:
(1) Cellular tumor antigen p53 (TP53)
(2) Glycogen synthase kinase-3 beta (GSK3B)

Interactions

Interaction #1 TP53 - GSK3B

Interfaces
(1) MOD_GSK3_1 motif (₃₀NVLSPLPS₃₇) in Cellular tumor antigen p53 (TP53)
(2) Protein kinase domain_(56-340) in Glycogen synthase kinase-3 beta (GSK3B)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S₃₇ on Cellular tumor antigen p53 (TP53)) of the Cellular tumor antigen p53 (TP53) MOD_GSK3_1 motif - Glycogen synthase kinase-3 beta (GSK3B) Protein kinase domain interaction

Regulatory Enzymes for switch
Modifying enzymes for residue: S₃₇: DNA-dependent protein kinase catalytic subunit (PRKDC)

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: S₃₇ : Serine/threonine-protein kinase ATR (ATR), Serine/threonine-protein kinase Chk1 (CHEK1), Serine/threonine-protein kinase Chk2 (CHEK2), MAP kinase-activated protein kinase 5 (MAPKAPK5), DNA-dependent protein kinase catalytic subunit (PRKDC).

Context

Switch localisation
ELM curated: cytosol, nucleus

Switch pathways

References

(1) Glycogen synthase kinase3 beta phosphorylates serine 33 of p53 and activates p53's transcriptional activity.
Turenne et al. BMC Cell Biol. (2001)