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Switch #:
SWTI000017
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Transcription factor AP-1 (JUN) at S243 primes the protein for phosphorylation at T239 by Glycogen synthase kinase-3 beta (GSK3B).

Participants:
(1) Transcription factor AP-1 (JUN)
(2) Glycogen synthase kinase-3 beta (GSK3B)

Interactions
Interaction #1 JUN - GSK3B

Interfaces
(1) MOD_GSK3_1 motif (236PGETPPLS243) in Transcription factor AP-1 (JUN)
(2) Protein kinase domain (56-340) in Glycogen synthase kinase-3 beta (GSK3B)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S243 on Transcription factor AP-1 (JUN)) of the Transcription factor AP-1 (JUN) MOD_GSK3_1 motif - Glycogen synthase kinase-3 beta (GSK3B) Protein kinase domain interaction

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: S243 : CK2_group, Glycogen synthase kinase-3 alpha (GSK3A), Casein kinase II subunit alpha (CSNK2A1), Glycogen synthase kinase-3 beta (GSK3B).

Context
Switch localisation
ELM curated: cytosol, nucleus
Inferred: cytosol


Switch pathways
Inferred: Neurotrophin signaling pathway, Wnt signaling pathway, T cell receptor signaling pathway, B cell receptor signaling pathway, ErbB signaling pathway, Focal adhesion
References

(1) Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity.
Boyle et al. Cell (1991)

See also

Other switches involving participants
Glycogen synthase kinase-3 beta (GSK3B) - 18 more (view)
Transcription factor AP-1 (JUN) - 3 more (view)

Other switches involving interfaces
Protein kinase domain - 35 more (view)
MOD_GSK3_1 - 18 more (view)


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