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Physicochemical compatibility

Phosphorylation of G1/S-specific cyclin-E1 (CCNE1) at S399 by Cyclin-dependent kinase 2 (CDK2) primes the protein for subsequent phosphorylation at T395 by Glycogen synthase kinase-3 beta (GSK3B).

(1) G1/S-specific cyclin-E1 (CCNE1)
(2) Glycogen synthase kinase-3 beta (GSK3B)

Interaction #1 CCNE1 - GSK3B

(1) MOD_GSK3_1 motif (392GLLTPPQS399) in G1/S-specific cyclin-E1 (CCNE1)
(2) Protein kinase domain (56-340) in Glycogen synthase kinase-3 beta (GSK3B)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S399 on G1/S-specific cyclin-E1 (CCNE1)) of the G1/S-specific cyclin-E1 (CCNE1) MOD_GSK3_1 motif - Glycogen synthase kinase-3 beta (GSK3B) Protein kinase domain interaction

Regulatory Enzymes for switch
Modifying enzymes for residue: S399: Cyclin-dependent kinase 2 (CDK2)

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: S399 : Cyclin-dependent kinase 2 (CDK2).


(1) Multisite phosphorylation by Cdk2 and GSK3 controls cyclin E degradation.
Welcker et al. Mol. Cell (2003)

See also

Other switches involving participants
Glycogen synthase kinase-3 beta (GSK3B) - 18 more (view)
G1/S-specific cyclin-E1 (CCNE1) - 2 more (view)

Other switches involving interfaces
Protein kinase domain - 35 more (view)
MOD_GSK3_1 - 18 more (view)

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