Switch #: SWTI000018

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of G1/S-specific cyclin-E1 (CCNE1) at S399 by Cyclin-dependent kinase 2 (CDK2) primes the protein for subsequent phosphorylation at T395 by Glycogen synthase kinase-3 beta (GSK3B).

Participants:
(1) G1/S-specific cyclin-E1 (CCNE1)
(2) Glycogen synthase kinase-3 beta (GSK3B)

(1) Multisite phosphorylation by Cdk2 and GSK3 controls cyclin E degradation.
Welcker et al. Mol. Cell (2003)

Other switches involving participants
Glycogen synthase kinase-3 beta (GSK3B) - 18 more (view)
G1/S-specific cyclin-E1 (CCNE1) - 2 more (view)

Other switches involving interfaces
Protein kinase domain - 35 more (view)
MOD_GSK3_1 - 18 more (view)