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Switch #:
SWTI000019
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Ataxin-3 (ATXN3) at S260 primes the protein for subsequent phosphorylation at S256 by Glycogen synthase kinase-3 beta (GSK3B).

Participants:
(1) Ataxin-3 (ATXN3)
(2) Glycogen synthase kinase-3 beta (GSK3B)

Interactions
Interaction #1 ATXN3 - GSK3B

Interfaces
(1) MOD_GSK3_1 motif (253IQLSMQGS260) in Ataxin-3 (ATXN3)
(2) Protein kinase domain (56-340) in Glycogen synthase kinase-3 beta (GSK3B)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S260 on Ataxin-3 (ATXN3)) of the Ataxin-3 (ATXN3) MOD_GSK3_1 motif - Glycogen synthase kinase-3 beta (GSK3B) Protein kinase domain interaction

Context
Switch localisation
ELM curated: cytosol, nucleus
References

(1) Phosphorylation of ataxin-3 by glycogen synthase kinase 3beta at serine 256 regulates the aggregation of ataxin-3.
Fei et al. Biochem. Biophys. Res. Commun. (2007)

See also

Other switches involving participants
Glycogen synthase kinase-3 beta (GSK3B) - 18 more (view)

Other switches involving interfaces
Protein kinase domain - 35 more (view)
MOD_GSK3_1 - 18 more (view)


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