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ELM:LIG_SH2_STAT5 (16 hits)
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Modifier evidence source
Curated
inferred
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Index
Epidermal growth factor receptor
Hepatocyte growth factor receptor
Insulin receptor
Proto-oncogene tyrosine-protein kinase LCK
(Mus)
Receptor tyrosine-protein kinase erbB-4
Tyrosine-protein kinase Fyn
(Mus)
Tyrosine-protein kinase JAK2
Tyrosine-protein kinase Lck
Motif
Protein
Start
End
Switch Type
Switch Subtype
Switch description
Information
Evidence
Epidermal growth factor receptor -
EGFR
-
Homo sapiens
LIG_SH2_STAT5
GAB1_HUMAN
472
475
Binary
Physicochemical compatibility
Phosphorylation of Y472 in the SH2-binding motif of
GRB2-associated-binding protein 1 (GAB1)
induces binding to
Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)
.
details
Inferred
LIG_SH2_STAT5
GAB1_HUMAN
472
475
Binary
Physicochemical compatibility
Phosphorylation of Y472 in the SH2-binding motif of
GRB2-associated-binding protein 1 (GAB1)
induces binding to
Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)
.
details
Inferred
LIG_SH2_STAT5
GAB1_HUMAN
447
450
Binary
Physicochemical compatibility
Phosphorylation of Y447 in the SH2-binding motif of
GRB2-associated-binding protein 1 (GAB1)
induces binding to
Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)
.
details
Inferred
LIG_SH2_STAT5
GAB1_HUMAN
447
450
Binary
Physicochemical compatibility
Phosphorylation of Y447 in the SH2-binding motif of
GRB2-associated-binding protein 1 (GAB1)
induces binding to
Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)
.
details
Inferred
Hepatocyte growth factor receptor -
MET
-
Homo sapiens
LIG_SH2_STAT5
GAB1_HUMAN
472
475
Binary
Physicochemical compatibility
Phosphorylation of Y472 in the SH2-binding motif of
GRB2-associated-binding protein 1 (GAB1)
induces binding to
Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)
.
details
Inferred
LIG_SH2_STAT5
GAB1_HUMAN
447
450
Binary
Physicochemical compatibility
Phosphorylation of Y447 in the SH2-binding motif of
GRB2-associated-binding protein 1 (GAB1)
induces binding to
Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)
.
details
Inferred
Insulin receptor -
INSR
-
Homo sapiens
LIG_SH2_STAT5
GAB1_HUMAN
472
475
Binary
Physicochemical compatibility
Phosphorylation of Y472 in the SH2-binding motif of
GRB2-associated-binding protein 1 (GAB1)
induces binding to
Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)
.
details
Inferred
LIG_SH2_STAT5
GAB1_HUMAN
472
475
Binary
Physicochemical compatibility
Phosphorylation of Y472 in the SH2-binding motif of
GRB2-associated-binding protein 1 (GAB1)
induces binding to
Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)
.
details
Inferred
LIG_SH2_STAT5
GAB1_HUMAN
447
450
Binary
Physicochemical compatibility
Phosphorylation of Y447 in the SH2-binding motif of
GRB2-associated-binding protein 1 (GAB1)
induces binding to
Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)
.
details
Inferred
LIG_SH2_STAT5
GAB1_HUMAN
447
450
Binary
Physicochemical compatibility
Phosphorylation of Y447 in the SH2-binding motif of
GRB2-associated-binding protein 1 (GAB1)
induces binding to
Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)
.
details
Inferred
Proto-oncogene tyrosine-protein kinase LCK -
LCK
-
Mus musculus
LIG_SH2_STAT5
CTLA4_MOUSE
201
204
Specificity
Altered binding specificity
Dephosphorylation of Y201 of
Cytotoxic T-lymphocyte protein 4 (Ctla4)
switches the specificity of
Ctla4
from SH2 domain-containing proteins like
Tyrosine-protein phosphatase non-receptor type 11 (Ptpn11)
to the AP-2 complex mu subunit (
AP-2 complex subunit mu (Ap2m1)
), thereby switching from inhibitory signal transmission and negative regulation of T cell responses to internalization and inactivation of
Ctla4
.
details
Inferred
Receptor tyrosine-protein kinase erbB-4 -
ERBB4
-
Homo sapiens
LIG_SH2_STAT5
ERBB4_HUMAN
1056
1059
Specificity
Altered binding specificity
Phosphorylation-dependent binding of
Receptor tyrosine-protein kinase erbB-4 (ERBB4)
to the SH2 domains of
Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)
results in signaling activation, while binding to the WW domains of
E3 ubiquitin-protein ligase Itchy homolog (ITCH)
to unphopshorylated
ERBB4
results in ubiquitylation, endocytosis and ultimately degradation of
ERBB4
.
details
Inferred
Tyrosine-protein kinase Fyn -
FYN
-
Mus musculus
LIG_SH2_STAT5
CTLA4_MOUSE
201
204
Specificity
Altered binding specificity
Dephosphorylation of Y201 of
Cytotoxic T-lymphocyte protein 4 (Ctla4)
switches the specificity of
Ctla4
from SH2 domain-containing proteins like
Tyrosine-protein phosphatase non-receptor type 11 (Ptpn11)
to the AP-2 complex mu subunit (
AP-2 complex subunit mu (Ap2m1)
), thereby switching from inhibitory signal transmission and negative regulation of T cell responses to internalization and inactivation of
Ctla4
.
details
Inferred
Tyrosine-protein kinase JAK2 -
JAK2
-
Homo sapiens
LIG_SH2_STAT5
CTLA4_MOUSE
201
204
Specificity
Altered binding specificity
Dephosphorylation of Y201 of
Cytotoxic T-lymphocyte protein 4 (Ctla4)
switches the specificity of
Ctla4
from SH2 domain-containing proteins like
Tyrosine-protein phosphatase non-receptor type 11 (Ptpn11)
to the AP-2 complex mu subunit (
AP-2 complex subunit mu (Ap2m1)
), thereby switching from inhibitory signal transmission and negative regulation of T cell responses to internalization and inactivation of
Ctla4
.
details
Inferred
LIG_SH2_STAT5
CTLA4_MOUSE
201
204
Specificity
Altered binding specificity
Dephosphorylation of Y201 of
Cytotoxic T-lymphocyte protein 4 (Ctla4)
switches the specificity of
Ctla4
from SH2 domain-containing proteins like
Tyrosine-protein phosphatase non-receptor type 11 (Ptpn11)
to the AP-2 complex mu subunit (
AP-2 complex subunit mu (Ap2m1)
), thereby switching from inhibitory signal transmission and negative regulation of T cell responses to internalization and inactivation of
Ctla4
.
details
Inferred
Tyrosine-protein kinase Lck -
LCK
-
Homo sapiens
LIG_SH2_STAT5
CTLA4_MOUSE
201
204
Specificity
Altered binding specificity
Dephosphorylation of Y201 of
Cytotoxic T-lymphocyte protein 4 (Ctla4)
switches the specificity of
Ctla4
from SH2 domain-containing proteins like
Tyrosine-protein phosphatase non-receptor type 11 (Ptpn11)
to the AP-2 complex mu subunit (
AP-2 complex subunit mu (Ap2m1)
), thereby switching from inhibitory signal transmission and negative regulation of T cell responses to internalization and inactivation of
Ctla4
.
details
Inferred
