switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Hide inferred Group Index Colouring Info Filtered: ELM:LIG_FHA_1 (13 hits) x

x Coloured by: Modifier evidence source
Curated inferred

x Index

DNA-dependent protein kinase catalytic subunit	Dual specificity protein kinase TTK	Mitogen-activated protein kinase kinase kinase MLT
NP_000042 (?)	Probable serine/threonine-protein kinase pknG (Mycobacterium)	Serine-protein kinase ATM
Serine/threonine-protein kinase ATR	Serine/threonine-protein kinase Chk2	Serine/threonine-protein kinase PLK1
Serine/threonine-protein kinase pknB (Mycobacterium)

Motif

Protein

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Information

Evidence

DNA-dependent protein kinase catalytic subunit - PRKDC - Homo sapiens
LIG_FHA_1	CHK2_HUMAN	66	72	Binary	Physicochemical compatibility	Phosphorylation of T68 in the FHA-binding motif of Serine/threonine-protein kinase Chk2 (CHEK2) induces binding to the Serine/threonine-protein kinase Chk2 (CHEK2) protein.	details	Inferred
Dual specificity protein kinase TTK - TTK - Homo sapiens
LIG_FHA_1	CHK2_HUMAN	66	72	Binary	Physicochemical compatibility	Phosphorylation of T68 in the FHA-binding motif of Serine/threonine-protein kinase Chk2 (CHEK2) induces binding to the Serine/threonine-protein kinase Chk2 (CHEK2) protein.	details	Inferred
LIG_FHA_1	CHK2_HUMAN	66	72	Binary	Physicochemical compatibility	Phosphorylation of T68 in the FHA-binding motif of Serine/threonine-protein kinase Chk2 (CHEK2) induces binding to the Serine/threonine-protein kinase Chk2 (CHEK2) protein.	details	Inferred
Mitogen-activated protein kinase kinase kinase MLT - MLTK - Homo sapiens
LIG_FHA_1	CHK2_HUMAN	66	72	Binary	Physicochemical compatibility	Phosphorylation of T68 in the FHA-binding motif of Serine/threonine-protein kinase Chk2 (CHEK2) induces binding to the Serine/threonine-protein kinase Chk2 (CHEK2) protein.	details	Inferred
NP_000042 - ? - ?
LIG_FHA_1	CHK2_HUMAN	66	72	Binary	Physicochemical compatibility	Phosphorylation of T68 in the FHA-binding motif of Serine/threonine-protein kinase Chk2 (CHEK2) induces binding to the Serine/threonine-protein kinase Chk2 (CHEK2) protein.	details	Inferred
Probable serine/threonine-protein kinase pknG - PKNG - Mycobacterium tuberculosis
LIG_FHA_1	Y1827_MYCTU	19	25	Binary	Physicochemical compatibility	Phosphorylation of T21 in the FHA-binding motif of Uncharacterized protein Rv1827/MT1875 (Rv1827) by Probable serine/threonine-protein kinase pknG (pknG) results in auto-inhibition due to an intramolecular interaction with the FHA domain. As a result, phosphorylation-independent interactions of the FHA domain with metabolic enzymes, which regulate the catalytic activity of these enzymes, are blocked (See also switch details).	details	Curated
Serine-protein kinase ATM - ATM - Homo sapiens
LIG_FHA_1	CHK2_HUMAN	66	72	Binary	Physicochemical compatibility	Phosphorylation of T68 in the FHA-binding motif of Serine/threonine-protein kinase Chk2 (CHEK2) induces binding to the Serine/threonine-protein kinase Chk2 (CHEK2) protein.	details	Inferred
Serine/threonine-protein kinase ATR - ATR - Homo sapiens
LIG_FHA_1	CHK2_HUMAN	66	72	Binary	Physicochemical compatibility	Phosphorylation of T68 in the FHA-binding motif of Serine/threonine-protein kinase Chk2 (CHEK2) induces binding to the Serine/threonine-protein kinase Chk2 (CHEK2) protein.	details	Inferred
Serine/threonine-protein kinase Chk2 - CHEK2 - Homo sapiens
LIG_FHA_1	CHK2_HUMAN	66	72	Binary	Physicochemical compatibility	Phosphorylation of T68 in the FHA-binding motif of Serine/threonine-protein kinase Chk2 (CHEK2) induces binding to the Serine/threonine-protein kinase Chk2 (CHEK2) protein.	details	Inferred
LIG_FHA_1	CHK2_HUMAN	66	72	Binary	Physicochemical compatibility	Phosphorylation of T68 in the FHA-binding motif of Serine/threonine-protein kinase Chk2 (CHEK2) induces binding to the Serine/threonine-protein kinase Chk2 (CHEK2) protein.	details	Inferred
Serine/threonine-protein kinase PLK1 - PLK1 - Homo sapiens
LIG_FHA_1	CHK2_HUMAN	66	72	Binary	Physicochemical compatibility	Phosphorylation of T68 in the FHA-binding motif of Serine/threonine-protein kinase Chk2 (CHEK2) induces binding to the Serine/threonine-protein kinase Chk2 (CHEK2) protein.	details	Inferred
LIG_FHA_1	CHK2_HUMAN	66	72	Binary	Physicochemical compatibility	Phosphorylation of T68 in the FHA-binding motif of Serine/threonine-protein kinase Chk2 (CHEK2) induces binding to the Serine/threonine-protein kinase Chk2 (CHEK2) protein.	details	Inferred
Serine/threonine-protein kinase pknB - PKNB - Mycobacterium tuberculosis
LIG_FHA_1	Y1827_MYCTU	20	26	Binary	Physicochemical compatibility	Phosphorylation of T22 in the FHA-binding motif of Uncharacterized protein Rv1827/MT1875 (Rv1827) by Serine/threonine-protein kinase pknB (pknB) results in auto-inhibition due to an intramolecular interaction with the FHA domain. As a result, phosphorylation-independent interactions of the FHA domain with metabolic enzymes, which regulate the catalytic activity of these enzymes, are blocked (See also switch details).	details	Curated