switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Hide inferred Group Index Colouring Info Filtered: ELM:TRG_AP2beta_CARGO_2 (1 hits) x

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Cyclin-dependent kinase 5 - CDK5 - Mus musculus
TRG_AP2beta_CARGO_2	PI51C_MOUSE	633	644	Binary	Physicochemical compatibility	Phosphorylation of S645 in Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma (Pip5k1c) impedes binding to AP-2 complex subunit beta (Ap2b1), while dephosphorylation by calcineurin promotes binding. These phosphorylation and dephosphorylation events are important for the regulation of clathrin coat formation associated with synaptic vesicles.	details	Curated