switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Hide inferred Group Index Colouring Info Filtered: UNIPROT:O43613 (4 hits) x

x Coloured by: Modifier evidence source
Curated inferred

x Index

Proto-oncogene tyrosine-protein kinase Src

Motif

Protein

Start

End

Switch Type

Switch Subtype

Switch description

Information

Evidence

Proto-oncogene tyrosine-protein kinase Src - SRC - Homo sapiens
LIG_TYR_ITSM	OX1R_HUMAN	79	86	Avidity‑sensing	Orexin-A induced phosphorylation of the ITSM and ITIM motifs in Orexin receptor type 1 (HCRTR1) allows binding of Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) via its two SH2 domains. Mutation of either tyrosine in the motifs abolishes binding of Tyrosine-protein phosphatase non-receptor type 11 (PTPN11).	details	Inferred
LIG_TYR_ITIM	OX1R_HUMAN	356	361	Avidity‑sensing	Orexin-A induced phosphorylation of the ITSM and ITIM motifs in Orexin receptor type 1 (HCRTR1) allows binding of Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) via its two SH2 domains. Mutation of either tyrosine in the motifs abolishes binding of Tyrosine-protein phosphatase non-receptor type 11 (PTPN11).	details	Inferred
LIG_TYR_ITSM	OX1R_HUMAN	79	86	Avidity‑sensing	Orexin-A induced phosphorylation of the ITSM and ITIM motifs in Orexin receptor type 1 (HCRTR1) allows binding of Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) via its two SH2 domains. Mutation of either tyrosine in the motifs abolishes binding of Tyrosine-protein phosphatase non-receptor type 11 (PTPN11).	details	Inferred
LIG_TYR_ITIM	OX1R_HUMAN	356	361	Avidity‑sensing	Orexin-A induced phosphorylation of the ITSM and ITIM motifs in Orexin receptor type 1 (HCRTR1) allows binding of Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) via its two SH2 domains. Mutation of either tyrosine in the motifs abolishes binding of Tyrosine-protein phosphatase non-receptor type 11 (PTPN11).	details	Inferred