switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Hide inferred Group Index Colouring Info Filtered: UNIPROT:P06241 (9 hits) x

x Coloured by: Modifier evidence source
Curated inferred

x Index

Activated CDC42 kinase 1	Proto-oncogene tyrosine-protein kinase Src	Tyrosine-protein kinase ABL1
Tyrosine-protein kinase BTK	Tyrosine-protein kinase Fyn	Tyrosine-protein kinase HCK
Tyrosine-protein kinase HCK (Mus)	Tyrosine-protein kinase Lck	Tyrosine-protein kinase Lyn

Motif

Protein

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Evidence

Activated CDC42 kinase 1 - TNK2 - Homo sapiens
LIG_GBD_WASP_1	WASP_HUMAN	466	476	Uncategorised	Uncategorised	Phosphorylation of Wiskott-Aldrich syndrome protein (WAS) at Y291 by Src kinases, e.g. , destabilises the auto-inhibitory intramolecular interaction of Wiskott-Aldrich syndrome protein (WAS).	details	Inferred
Proto-oncogene tyrosine-protein kinase Src - SRC - Homo sapiens
LIG_SH2_SRC	DAG1_HUMAN	892	895	Specificity	Altered binding specificity	Adhesion-dependent phosphorylation of Y892 in Dystroglycan (DAG1) by Src kinase (Proto-oncogene tyrosine-protein kinase Src (SRC)) switches the specificity of DAG1 from the WW domain containing cytoskeletal linker Dystrophin (DMD) to the SH2 domain containing Tyrosine-protein kinase Fyn (FYN).	details	Inferred
Tyrosine-protein kinase ABL1 - ABL1 - Homo sapiens
LIG_GBD_WASP_1	WASP_HUMAN	466	476	Uncategorised	Uncategorised	Phosphorylation of Wiskott-Aldrich syndrome protein (WAS) at Y291 by Src kinases, e.g. , destabilises the auto-inhibitory intramolecular interaction of Wiskott-Aldrich syndrome protein (WAS).	details	Inferred
Tyrosine-protein kinase BTK - BTK - Homo sapiens
LIG_GBD_WASP_1	WASP_HUMAN	466	476	Uncategorised	Uncategorised	Phosphorylation of Wiskott-Aldrich syndrome protein (WAS) at Y291 by Src kinases, e.g. , destabilises the auto-inhibitory intramolecular interaction of Wiskott-Aldrich syndrome protein (WAS).	details	Inferred
Tyrosine-protein kinase Fyn - FYN - Homo sapiens
LIG_GBD_WASP_1	WASP_HUMAN	466	476	Uncategorised	Uncategorised	Phosphorylation of Wiskott-Aldrich syndrome protein (WAS) at Y291 by Src kinases, e.g. , destabilises the auto-inhibitory intramolecular interaction of Wiskott-Aldrich syndrome protein (WAS).	details	Curated
Tyrosine-protein kinase HCK - HCK - Homo sapiens
LIG_GBD_WASP_1	WASP_HUMAN	466	476	Uncategorised	Uncategorised	Phosphorylation of Wiskott-Aldrich syndrome protein (WAS) at Y291 by Src kinases, e.g. , destabilises the auto-inhibitory intramolecular interaction of Wiskott-Aldrich syndrome protein (WAS).	details	Curated
Tyrosine-protein kinase HCK - HCK - Mus musculus
LIG_GBD_WASP_1	WASP_HUMAN	466	476	Uncategorised	Uncategorised	Phosphorylation of Wiskott-Aldrich syndrome protein (WAS) at Y291 by Src kinases, e.g. , destabilises the auto-inhibitory intramolecular interaction of Wiskott-Aldrich syndrome protein (WAS).	details	Inferred
Tyrosine-protein kinase Lck - LCK - Homo sapiens
LIG_GBD_WASP_1	WASP_HUMAN	466	476	Uncategorised	Uncategorised	Phosphorylation of Wiskott-Aldrich syndrome protein (WAS) at Y291 by Src kinases, e.g. , destabilises the auto-inhibitory intramolecular interaction of Wiskott-Aldrich syndrome protein (WAS).	details	Inferred
Tyrosine-protein kinase Lyn - LYN - Homo sapiens
LIG_GBD_WASP_1	WASP_HUMAN	466	476	Uncategorised	Uncategorised	Phosphorylation of Wiskott-Aldrich syndrome protein (WAS) at Y291 by Src kinases, e.g. , destabilises the auto-inhibitory intramolecular interaction of Wiskott-Aldrich syndrome protein (WAS).	details	Inferred