Switch #: SWTI000210

Switch type: Uncategorised

Switch subtype: Uncategorised

Description:
Phosphorylation of Wiskott-Aldrich syndrome protein (WAS) at Y291 by Src kinases, e.g. , destabilises the auto-inhibitory intramolecular interaction of Wiskott-Aldrich syndrome protein (WAS).

Participants:
(1) Wiskott-Aldrich syndrome protein (WAS)

(1) Physical mechanisms of signal integration by WASP family proteins.
Padrick et al. Annu. Rev. Biochem. (2010)

(2) Contingent phosphorylation/dephosphorylation provides a mechanism of molecular memory in WASP.
Torres et al. Mol. Cell (2003)

(3) Protein-tyrosine kinase and GTPase signals cooperate to phosphorylate and activate Wiskott-Aldrich syndrome protein (WASP)/neuronal WASP.
Torres et al. J. Biol. Chem. (2006)

(4) Phosphorylation of tyrosine 291 enhances the ability of WASp to stimulate actin polymerization and filopodium formation. Wiskott-Aldrich Syndrome protein.
Cory et al. J. Biol. Chem. (2002)

(5) Fyn and PTP-PEST-mediated regulation of Wiskott-Aldrich syndrome protein (WASp) tyrosine phosphorylation is required for coupling T cell antigen receptor engagement to WASp effector function and T cell activation.
Badour et al. J. Exp. Med. (2004)

Other switches involving participants
Wiskott-Aldrich syndrome protein (WAS) - 2 more (view)

Other switches involving interfaces
ELM:LIG_GBD_WASP_1 - 5 more (view)
P21-Rho-binding domain - 5 more (view)