Switch #: SWTI000211

Switch type: Uncategorised

Switch subtype: Uncategorised

Description:
Phosphorylation of Neural Wiskott-Aldrich syndrome protein (WASL) at Y256 destabilises the auto-inhibitory intramolecular interaction of Neural Wiskott-Aldrich syndrome protein (WASL).

Participants:
(1) Neural Wiskott-Aldrich syndrome protein (WASL)

(1) Protein-tyrosine kinase and GTPase signals cooperate to phosphorylate and activate Wiskott-Aldrich syndrome protein (WASP)/neuronal WASP.
Torres et al. J. Biol. Chem. (2006)

(2) Physical mechanisms of signal integration by WASP family proteins.
Padrick et al. Annu. Rev. Biochem. (2010)

(3) Phosphorylation of WASP by the Cdc42-associated kinase ACK1: dual hydroxyamino acid specificity in a tyrosine kinase.
Yokoyama et al. J. Biol. Chem. (2005)

Other switches involving participants
Neural Wiskott-Aldrich syndrome protein (WASL) - 2 more (view)

Other switches involving interfaces
ELM:LIG_GBD_WASP_1 - 5 more (view)
P21-Rho-binding domain - 5 more (view)