switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Hide inferred Group Index Colouring Info Filtered: UNIPROT:Q14118 (4 hits) x

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Curated inferred

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Proto-oncogene tyrosine-protein kinase Src

Motif

Protein

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Evidence

Proto-oncogene tyrosine-protein kinase Src - SRC - Homo sapiens
LIG_WW_1	DAG1_HUMAN	889	892	Specificity	Altered binding specificity	Adhesion-dependent phosphorylation of Y892 in Dystroglycan (DAG1) by Src kinase (Proto-oncogene tyrosine-protein kinase Src (SRC)) switches the specificity of DAG1 from the WW domain containing cytoskeletal linker Dystrophin (DMD) to the SH2 domain containing Tyrosine-protein kinase Fyn (FYN).	details	Inferred
LIG_SH2_SRC	DAG1_HUMAN	892	895	Specificity	Altered binding specificity	Adhesion-dependent phosphorylation of Y892 in Dystroglycan (DAG1) by Src kinase (Proto-oncogene tyrosine-protein kinase Src (SRC)) switches the specificity of DAG1 from the WW domain containing cytoskeletal linker Dystrophin (DMD) to the SH2 domain containing Tyrosine-protein kinase Fyn (FYN).	details	Inferred
LIG_WW_1	DAG1_HUMAN	889	892	Specificity	Altered binding specificity	Adhesion-dependent phosphorylation of Y892 in Dystroglycan (DAG1) by c-Src (SRC) switches the specificity of DAG1 from WW domain containing proteins like Utrophin (UTRN) to SH2 domain containing proteins like Tyrosine-protein kinase CSK (CSK).	details	Inferred
LIG_SH2_SRC	DAG1_HUMAN	892	895	Specificity	Altered binding specificity	Adhesion-dependent phosphorylation of Y892 in Dystroglycan (DAG1) by c-Src (SRC) switches the specificity of DAG1 from WW domain containing proteins like Utrophin (UTRN) to SH2 domain containing proteins like Tyrosine-protein kinase CSK (CSK).	details	Inferred