switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Show inferred Group Index Colouring Info Filtered: ELM:DEG_SCF_TRCP1_1 (3 hits) x

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Curated inferred

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Protein

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Information

Evidence

Oocyte meiosis (KEGG - hsa04114)
DEG_SCF_TRCP1_1	FBX5_HUMAN	144	149	Binary	Physicochemical compatibility	Dual phosphorylation of S145 and S149 in the TrCP1-binding motif of F-box only protein 5 (FBXO5) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.	details	Curated
SCF-beta-TrCP mediated degradation of Emi1 (Reactome - 174113)
DEG_SCF_TRCP1_1	FBX5_HUMAN	144	149	Binary	Physicochemical compatibility	Dual phosphorylation of S145 and S149 in the TrCP1-binding motif of F-box only protein 5 (FBXO5) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.	details	Curated
Wnt signaling pathway (KEGG - hsa04310)
DEG_SCF_TRCP1_1	CTNB1_HUMAN	32	37	Specificity	Altered binding specificity	Phosphorylation of Catenin beta-1 (CTNNB1) at T41 generates a docking site for Glycogen synthase kinase-3 beta (GSK3B), which then phosphorylates S37, thereby generating a new docking site for GSK3B. Subsequent phosphorylation of S33 by GSK3B switches the specificity of CTNNB1 to the F-box/WD repeat-containing protein 1A (BTRC), which recruits CTNNB1 to the SCF ubiquitin ligase complex.	details	Curated