switches.ELM

Group by :Switch type Motif class Protein Enzyme Pathway Show inferred Group Index Colouring Info Filtered: UNIPROT:P42574 (3 hits) x

x Coloured by: Pathway evidence source
Curated inferred

x Index

Motif

Protein

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Information

Evidence

Apoptosis (KEGG - hsa04210)
CLV_C14_caspase-8-10	CASP3_HUMAN	172	175	Binary	Physicochemical compatibility	Phosphorylation of S176 adjacent to the cleavage motif of Caspase-3 (CASP3) by CK2 subfamily prevents cleavage by Caspase-8 (CASP8) and thus activation of Caspase-3 (CASP3).	details	Curated
Apoptotic execution phase (Reactome - 75153)
CLV_C14_caspase-8-10	CASP3_HUMAN	172	175	Binary	Physicochemical compatibility	Phosphorylation of S176 adjacent to the cleavage motif of Caspase-3 (CASP3) by CK2 subfamily prevents cleavage by Caspase-8 (CASP8) and thus activation of Caspase-3 (CASP3).	details	Curated
CLV_C14_Caspase3-7	KPCD_HUMAN	326	330	Binary	Pre‑translational	Alternative splicing inserts exons within the Caspase-3 scission motif of Protein kinase C delta type (PRKCD), abrogating binding to Caspase-3 (CASP3). Cleavage of PKCdeltaI Protein kinase C delta type (PRKCD) by caspase-3 releases a catalytically active C-terminal fragment that is sufficient to induce apoptosis. This inserted exon disrupts scission motifs and therefore the PKCdeltaVIII (GENBANK:DQ516383) splice variant functions as an anti-apoptotic protein in NT2 cells.	details	Curated