Switch #: SWTI000121

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of S990 in the BRCT-binding motif of Fanconi anemia group J protein (BRIP1) induces binding to the Breast cancer type 1 susceptibility protein (BRCA1) protein.

Participants:
(1) Fanconi anemia group J protein (BRIP1)
(2) Breast cancer type 1 susceptibility protein (BRCA1)

(1) The BRCT domain is a phospho-protein binding domain.
Yu et al. Science (2003)

(2) Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer.
Clapperton et al. Nat. Struct. Mol. Biol. (2004)

Other switches involving participants
Breast cancer type 1 susceptibility protein (BRCA1) - 6 more (view)
Fanconi anemia group J protein (BRIP1) - 1 more (view)

Other switches involving interfaces
LIG_BRCT_BRCA1_1 - 4 more (view)
BRCA1 C Terminus (BRCT) domain - 6 more (view)