Switches.ELM

Switch #:

SWTI000159

Switch type:
Binary

Switch subtype:
Physicochemical compatibility

Description:
Dual phosphorylation of S52 and S56 in the TrCP1-binding motif of Protein Vpu (vpu) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.

Participants:
(1) Protein Vpu (vpu)
(2) F-box/WD repeat-containing protein 1A (BTRC)

Interactions

Interaction #1 vpu - BTRC

Interfaces
(1) DEG_SCF_TRCP1_1 motif (₅₁DSGNES₅₆) in Protein Vpu (vpu)
(2) WD domain, G-beta repeat_(297-329) and _(333-369) and _(373-409) and _(416-452) and _(456-492) and _(496-532) and _(545-581) in F-box/WD repeat-containing protein 1A (BTRC)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S₅₂ and S₅₆ on Protein Vpu (vpu)) of the Protein Vpu (vpu) DEG_SCF_TRCP1_1 motif - F-box/WD repeat-containing protein 1A (BTRC) WD domain, G-beta repeat interaction

Context

Switch localisation
ELM curated: nucleoplasm, nucleus, Chromosome, cytosol

Inferred: cytosol

References

(1) HIV-1 Vpu sequesters beta-transducin repeat-containing protein (betaTrCP) in the cytoplasm and provokes the accumulation of beta-catenin and other SCFbetaTrCP substrates.
Besnard-Guerin et al. J. Biol. Chem. (2004)