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Physicochemical compatibility

Dual phosphorylation of S52 and S56 in the TrCP1-binding motif of Protein Vpu (vpu) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.

(1) Protein Vpu (vpu)
(2) F-box/WD repeat-containing protein 1A (BTRC)

Interaction #1 vpu - BTRC

(1) DEG_SCF_TRCP1_1 motif (51DSGNES56) in Protein Vpu (vpu)
(2) WD domain, G-beta repeat (297-329) and (333-369) and (373-409) and (416-452) and (456-492) and (496-532) and (545-581) in F-box/WD repeat-containing protein 1A (BTRC)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S52 and S56 on Protein Vpu (vpu)) of the Protein Vpu (vpu) DEG_SCF_TRCP1_1 motif - F-box/WD repeat-containing protein 1A (BTRC) WD domain, G-beta repeat interaction


(1) HIV-1 Vpu sequesters beta-transducin repeat-containing protein (betaTrCP) in the cytoplasm and provokes the accumulation of beta-catenin and other SCFbetaTrCP substrates.
Besnard-Guerin et al. J. Biol. Chem. (2004)

See also

Other switches involving participants
F-box/WD repeat-containing protein 1A (BTRC) - 17 more (view)

Other switches involving interfaces
WD domain, G-beta repeat - 36 more (view)
DEG_SCF_TRCP1_1 - 17 more (view)

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